Stimulate discussion and debate as to the need for innovative, pragmatic solutions to developing “real-world” comparative effectiveness evidence that is affordable, timely and useful for health care decision making

Raise awareness of scientifically sound, innovative clinical study methods and practices which may contribute to more efficient methods of producing useful real-world comparative evidence

Function as a catalyst to evaluate novel clinical trial designs: specifically Bayesian adaptive design approaches for pragmatic comparative trials

Develop consensus among key stakeholders as to specific pragmatic approaches to novel comparative trial designs

Stimulate realistic, efficient alternatives for medical products manufacturers to invest in peri-approval comparative effectiveness studies which meet evidence requirements of clinicians, payers and regulators

Stimulate realistic, efficient alternative comparative trial research designs for publicly-funded comparative effectiveness clinical studies.